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. 2020 Jul 31;10:12991. doi: 10.1038/s41598-020-69822-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relative contribution of the developmental lineage branches to fetal skin tissue. (a) Lineage trees of a gestational age (GA) week 14 D21 fetus, (b) gestational age week 14,5 T21 fetus, (c) gestational age week 16 D21 fetus and (d) gestational age week 12 T21 fetus. Each tip represents a single clonally expanded cell. The pie charts show the median contribution of the contributing mutations in a branch to the bulk skin tissue. The grey part of the pie chart indicates the total skin tissue, while the red part shows the contribution of a single branch to the skin tissue. The text in the pie charts shows how many of the mutations in that branch contributed to the skin tissue. Mutations not contributing to the skin tissue at all, are not used to calculate the median. Multiple pie charts in a single branch indicate that the mutations in that branch occurred during different cell divisions.