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. 2020 Jul 31;10:12991. doi: 10.1038/s41598-020-69822-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Somatic mutation patterns of preleukemic bulk blast cells from DS-associated myeloid preleukemia patients. (a) Comparison of the number of autosomal somatic base substitutions per genome per year for T21 fetal haematopoietic stem and progenitor cells (14 clones; 3 donors) and DS-associated myeloid preleukemia (6 donors). Points with the same color indicate single cells from the same subject. (linear mixed-effects model, two-tailed t-test). (b) 7-Spectrum of somatic base substitutions. The total number of somatic base substitutions is indicated.