Fig. 6.

KDM2B recruits RNA Pol II for Il6 gene transcriptional activation. a Immunoblot analysis of RNA Pol II and KDM2B in protein complexes immunoprecipitated with an anti-KDM2B antibody from lysates of peritoneal macrophages stimulated with LPS for the indicated times. b ChIP-qPCR analysis of RNA Pol II occupancy at the Il6 promoter in Kdm2b^−/− (KO) and Kdm2b^+/+ (WT) peritoneal macrophages stimulated with LPS for the indicated times. Data are from three independent experiments (b, mean ± s.e.m.) or are representative of three independent experiments with similar results (a). **P < 0.01