Table 1.
Mean and standard deviation of 287-SNP and 229-SNP polygenic risk scores.
| Mean PRS (SD) | Mean PRS (SD) | Mean PRS (SD) | Mean PRS (SD) | |||
|---|---|---|---|---|---|---|
| 287-SNP PRS | 287-SNP PRS | 229-SNP PRS | 229-SNP PRS | |||
| Cases, N | Controls, N | Cases | Control | Cases | Control | |
| Asian studies in BCAC | ||||||
| PRSOVERALL | 15,755 | 16,483 | 0.91 (0.554) | 0.69 (0.556) | 1.09 (0.537) | 0.88 (0.539) |
| PRSER+ | 10,477 | 16,483 | 0.89 (0.580) | 0.62 (0.592) | ||
| PRSER− | 4764 | 16,483 | 1.26 (0.543) | 1.07 (0.533) | ||
| Asian within American studies in BCAC | ||||||
| PRSOVERALL | 1507 | 1212 | 0.91 (0.560) | 0.75 (0.546) | 1.09 (0.545) | 0.93 (0.529) |
| PRSER+ | 1022 | 1212 | 0.89 (0.598) | 0.69 (0.583) | ||
| PRSER− | 280 | 1212 | 1.27 (0.513) | 1.12 (0.512) | ||
| Prospective cohort | ||||||
| PRSOVERALL | 413 | 9842 | 1.06 (0.539) | 0.85 (0.523) | ||
| European studies | ||||||
| PRSOVERALL | 5129 | 5285 | 0.44 (0.608) | 0.12 (0.597) | 0.72 (0.608) | 0.435 (0.556) |
| PRSER+ | 4233 | 5285 | 0.43 (0.651) | 0.05 (0.638) | ||
| PRSER− | 926 | 5285 | 0.78 (0.560) | 0.54 (0.567) |
The overall breast cancer (BC) PRS (PRSoverall) and oestrogen-receptor (ER)-positive PRS (PRSER+) and ER-negative PRS (PRSER−) were derived as describe in the “Method” section. ER-subtype is not available for the prospective cohort. Mean and SD of PRS in European studies were calculated using the data on the validation set as described in Mavaddat et. al.7 but samples with missing ages information were removed. BCAC Breast Cancer Association consortium, SD standard deviation, PRS polygenic risk scores.