Table 3.

First-degree family history of breast cancer and breast cancer risk in Asian studies.

	Unadjusted for PRS, OR* (95% CI)	Adjusted for PRS, OR (95% CI)	Attenuation (%)a
Overall BC	1.35 (1.22–1.48)	1.31 (1.18–1.45)	10.0
ER-positive	1.36 (1.22–1.53)	1.33 (1.19–1.49)	7.3
ER-negative	1.21 (1.05–1.39)	1.18 (1.03–1.37)	13.2

PRS was computed based on 287 SNPs. ^*Odds ratio for developing breast cancer for women with a family history of breast cancer in a first-degree relative compared with women without a family history, adjusted for study and 10 principal components. All the case–control studies listed in Supplementary Table 1 were included in this analysis, except for SEBCS and SGBCC Batch 2. Family history information was not available for all cases in SEBCS (genotyped on Oncoarray) and all controls for SGBCC Batch 2 hence excluded from the analyses.

^aPercent attenuation on log scale.