Table 4.
Chinese Cases | Chinese Controls | Malay Cases | Malay Controls | Indian Cases | Indian Controls | |
N | ||||||
Overall BC | 5236 | 5156 | 1084 | 1332 | 580 | 1018 |
ER-positive | 3627 | 5156 | 715 | 1332 | 374 | 1018 |
ER-negative | 1365 | 5156 | 336 | 1332 | 184 | 1018 |
Age, years, mean (SD) | 53.1 (10.93) | 51.8 (9.73) | 49.7 (10.18) | 51.1 (8.73) | 53.2 (10.53) | 54.1 (8.75) |
Polygenic risk score, mean (SD) | ||||||
PRSoverall | 0.91 (0.54) | 0.69 (0.54) | 0.85 (0.58) | 0.63 (0.58) | 0.56 (0.57) | 0.33 (0.61) |
PRSER+ | 0.89 (0.57) | 0.63 (0.58) | 0.84 (0.59) | 0.57 (0.62) | 0.55 (0.57) | 0.26 (0.65) |
PRSER− | 1.24 (0.53) | 1.07 (0.52) | 1.11 (0.55) | 0.98 (0.55) | 0.92 (0.57) | 0.75 (0.55) |
N is the number of samples for cases and control in each subtype and ethnicity. Age is age of consent for controls and age of cancer diagnosis for cases. Mean and SD of age of cancer diagnosis were calculated using overall breast cancer (BC) cases. PRS was computed based on 287 SNPs. Mean and SD of PRSoverall, PRSER+ and PRSER− in cases were calculated using all cases, ER-positive cases and ER-negative cases, respectively. Self-declared ethnicity was used.