Skip to main content
. 2020 Jul 31;11:3833. doi: 10.1038/s41467-020-17680-w

Table 4.

Characteristics of women in Malaysian Breast Cancer Genetic Study and Singapore Breast Cancer Cohort.

Chinese Cases Chinese Controls Malay Cases Malay Controls Indian Cases Indian Controls
N
Overall BC 5236 5156 1084 1332 580 1018
ER-positive 3627 5156 715 1332 374 1018
ER-negative 1365 5156 336 1332 184 1018
Age, years, mean (SD) 53.1 (10.93) 51.8 (9.73) 49.7 (10.18) 51.1 (8.73) 53.2 (10.53) 54.1 (8.75)
Polygenic risk score, mean (SD)
PRSoverall 0.91 (0.54) 0.69 (0.54) 0.85 (0.58) 0.63 (0.58) 0.56 (0.57) 0.33 (0.61)
PRSER+ 0.89 (0.57) 0.63 (0.58) 0.84 (0.59) 0.57 (0.62) 0.55 (0.57) 0.26 (0.65)
PRSER− 1.24 (0.53) 1.07 (0.52) 1.11 (0.55) 0.98 (0.55) 0.92 (0.57) 0.75 (0.55)

N is the number of samples for cases and control in each subtype and ethnicity. Age is age of consent for controls and age of cancer diagnosis for cases. Mean and SD of age of cancer diagnosis were calculated using overall breast cancer (BC) cases. PRS was computed based on 287 SNPs. Mean and SD of PRSoverall, PRSER+ and PRSER− in cases were calculated using all cases, ER-positive cases and ER-negative cases, respectively. Self-declared ethnicity was used.