Table 2.
Adjusted odds ratio (OR) for respiratory and grip weakness, and impaired chair stands, stratified by antiHTN class and number used, respectively a
| AntiHTN | Respiratory Weakness b Adjusted OR (95%CI) e |
Grip Weakness c Adjusted OR (95%CI) e |
Impaired Chair Stands d Adjusted OR (95%CI) e |
|---|---|---|---|
| Class f | |||
| Diuretic | 0.85 (0.61, 1.19) | 1.00 (0.79, 1.26) | 0.89 (0.68, 1.16) |
| ACEi or ARB | 1.09 (0.78, 1.52) | 0.91 (0.72, 1.15) | 1.17 (0.89, 1.53) |
| CCB | 1.07 (0.76, 1.53) | 0.77 (0.60, 0.99) | 0.84 (0.64, 1.11) |
| BB | 1.07 (0.76, 1.50) | 1.02 (0.81, 1.29) | 0.95 (0.73, 1.24) |
| Number used g | |||
| One | 1.18 (0.74, 1.88) | 0.90 (0.65, 1.25) | 0.88 (0.60, 1.29) |
| Two | 1.39 (0.85, 2.27) | 0.83 (0.59, 1.16) | 0.72 (0.49, 1.06) |
| Three or more | 1.00 (0.59, 1.69) | 0.80 (0.56, 1.14) | 0.98 (0.65, 1.47) |
Abbreviations: ACEi, angiotensin converting enzyme; AntiHTN, antihypertensive; ARB, angiotensin receptor blocker; BB, beta blocker; CCB, calcium channel blocker; BMI, body mass index; CI, confidence interval; LLN, lower limit of normal; SPPB, Short Physical Performance Battery.
Because some characteristics had >5% missing data, multiple imputation was applied (see Statistical Analysis section).
Maximal inspiratory pressure (cm H2O) <LLN.
Threshold values for establishing weakness are stratified by gender and BMI.
Scores of 0–2 points on five chair stands, specifically a time ≥13.7 seconds to complete the task or unable to rise from the chair without use of the participant’s arms.
Adjusted for age, female gender, non-white race, obesity (BMI ≥30), never-smoker, comorbidities, and non-antiHTN medications.
Comparisons were between medication regimens that included a specified antiHTN class (e.g. diuretic) vs. medication regimens that did not include the specified antiHTN class (e.g. diuretic).
Comparison is use of one, two, or three or more antiHTN medications vs. no antiHTN medication, respectively.