Table 3.
Adjusted odds ratio (OR) for impaired balance, slow gait speed and mobility impairment, stratified by antiHTN class and number used, respectively a
| AntiHTN | Impaired Balance b Adjusted OR (95%CI) e |
Slow Gait Speed c Adjusted OR (95%CI) e |
Mobility Impairment d Adjusted OR (95%CI) e |
|---|---|---|---|
| Class f | |||
| Diuretic | 1.04 (0.84, 1.30) | 1.17 (0.94, 1.47) | 1.13 (0.91, 1.41) |
| ACEi or ARB | 0.91 (0.73, 1.14) | 1.05 (0.84, 1.32) | 0.96 (0.77, 1.19) |
| CCB | 1.18 (0.93, 1.49) | 1.23 (0.96, 1.56) | 0.96 (0.76, 1.22) |
| BB | 1.15 (0.92, 1.43) | 0.97 (0.78, 1.22) | 1.20 (0.97, 1.50) |
| Number used g | |||
| One | 1.34 (0.98, 1.82) | 0.93 (0.69, 1.27) | 1.10 (0.81, 1.50) |
| Two | 1.06 (0.77, 1.46) | 1.14 (0.83, 1.58) | 0.82 (0.59, 1.13) |
| Three or more | 1.34 (0.96, 1.86) | 1.20 (0.86, 1.68) | 1.37 (0.99, 1.91) |
Abbreviations: ACEi, angiotensin converting enzyme; AntiHTN, antihypertensive; ARB, angiotensin receptor blocker; BB, beta blocker; CCB, calcium channel blocker; BMI, body mass index; CI, confidence interval; SPPB, Short Physical Performance Battery; 400MWT, 400m walk test.
Because some characteristics had >5% missing data, multiple imputation was applied (see Statistical Analysis section).
Scores of 0–2 points on testing of side-by-side, semi-tandem, and tandem stands.
400-MWT gait speed < 48 meters/minute (< 0.8 meters/second).
SPPB total score ≤7 (moderate-to-severe).
Adjusted for age, gender, race, obesity (BMI ≥30), smoking status, comorbidities, and non-antiHTN medications.
Comparisons were between medication regimens that included a specified antiHTN class (e.g. diuretic) vs. medication regimens that did not include the specified antiHTN class (e.g. diuretic).
Comparison is use of one, two, or three or more antiHTN medications vs. no antiHTN medication, respectively.