Table 4.
Adjusted odds ratio (OR) for high sedentary time, dyspnea, and fatigue, stratified by antiHTN class and number used, respectively a
| AntiHTN | High Sedentary Time b Adjusted OR (95%CI) e |
Dyspnea c Adjusted OR (95%CI) e |
Fatigue d Adjusted OR (95%CI) e |
|---|---|---|---|
| Class f | |||
| Diuretic | 1.03 (0.78, 1.35) | 1.03 (0.82, 1.30) | 0.72 (0.53, 0.97) |
| ACEi or ARB | 1.00 (0.75, 1.34) | 1.11 (0.88, 1.40) | 0.90 (0.67, 1.21) |
| CCB | 0.93 (0.70, 1.24) | 1.06 (0.83, 1.36) | 1.07 (0.78, 1.47) |
| BB | 1.44 (1.12, 1.85) | 1.12 (0.89, 1.41) | 1.20 (0.89, 1.61) |
| Number used g | |||
| One | 1.15 (0.80, 1.67) | 0.96 (0.69, 1.34) | 1.11 (0.73, 1.69) |
| Two | 0.96 (0.66, 1.42) | 1.08 (0.77, 1.51) | 1.14 (0.74, 1.76) |
| Three or more | 1.52 (1.04, 2.23) | 1.20 (0.85, 1.70) | 0.81 (0.51, 1.28) |
Abbreviations: ACEi, angiotensin converting enzyme; AntiHTN, antihypertensive; ARB, angiotensin receptor blocker; ATS, American Thoracic Society; BB, beta blocker; CCB, calcium channel blocker; BMI, body mass index; CI, confidence interval; MEFI, Modified Exercise-induced Feeling Inventory; SPPB, Short Physical Performance Battery.
Because some characteristics had >5% missing data [Statistical Analysis section]), multiple imputation was applied.
Highest quartile in percent of accelerometry wear-time with activity <100 counts/minute (approximated sitting time).
ATS grade ≥2 (moderate-to-severe).
MEFI rating ≥3 established fatigue as occurring “good bit- to all-of-the-time during the past week”.
Adjusted for age, female gender, non-white race, obesity (BMI ≥30), never-smoker, comorbidities, and non-antiHTN medications.
Comparisons were between medication regimens that included a specified antiHTN class (e.g. diuretic) vs. medication regimens that did not include the specified antiHTN class (e.g. diuretic).
Comparison is use of one, two, or three or more antiHTN medications vs. no antiHTN medication, respectively.