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. 2020 Jul 31;6:69. doi: 10.1038/s41420-020-00293-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — NLRP3 is showed in red fluorescence, Nissl-like fluorescent marker Neurotrace visualized in green. a–l Immunoreaction intensity of NLRP3 in each animal group at the different time points. Two-way ANOVA analysis performed on data obtained by 4 and 13 weeks old Wt and 4 and 13 weeks old R6/2 mice showed a statistically significant effect of Genotype (F1,36 = 108,9; P < 0.001), Time (F1,36 = 20.00; P < 0.001) and Genotype X Time Interaction (F1,36 = 268,9; P < 0.001) of NLRP3 positive striatal neurons. m, n Histogram shows NLRP3 intensity quantification, that is significantly increased in the striatal neurons of 13 week-old R6/2 mice [Genotype effect F1,36 = 34,96; P < 0.001; Time effect F1,36 = 6,830; P < 0.05; Genotype X Time Interection F1,36 = 78,04; P < 0.001].