Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 31;6:69. doi: 10.1038/s41420-020-00293-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — Confocal microscopy-acquired images of double-label immunofluorescence for Calbindin and NLRP3. Calbindin is showed in green fluorescence, NLRP3 is labelled in red. a–l Images show the immunoreaction intensity of Calbindin and NLRP3 in each experimental group. Calbindin positive neurons and intensity were dramatically decreased in projection neurons of 13 weeks old R6/2 mice F1,36 = 27,57; p < 0.001. m, n Two way ANOVA analysis performed on data obtained by 4 and 13 weeks old Wt and 4 and 13 weeks old R6/2 mice showed a statistically significant effect of Genotype (F1,36 = 108,9; P < 0.001), Time (F1,36 = 20.00; P < 0.001) and GenotypeXTime Interection (F1,36 = 268,9; P < 0.001) on NLRP3 positive striatal neurons. o Quantitative analysis of coexpression levels by Mander’s coefficient in all experimental groups. Histogram represented the mean of ROIs calculated Mander’s coefficients revealed the statistically significant colocalization of NLRP3 in Calbindin positive neurons P < 0.001.