Table 3.
Comparison of virus-positive and -negative groups.
| Positive (n = 3) | Negative (n = 26) | p value | |
|---|---|---|---|
| Age (±SD) | 76 (±3.0) | 73 (±9.2) | N.S. |
| Male (%) | 2 (66) | 19 (73) | N.S. |
| BMI (±SD) | 23.8 (±5.9) | 21.7 (±4.4) | N.S. |
| WBC (±SD) | 12700 (±3935) | 10465 (±3124) | N.S. |
| CRP (±SD) | 11.3 (±6.8) | 9.7 (±6.3) | N.S. |
| LDH (±SD) | 314 (±97) | 320 (±84) | N.S. |
| KL-6 (±SD) | 646 (±192) | 1019 (±550) | N.S. |
| FVC (±SD) | 2.41 (±1.34) | 2.24 (±1.08) | N.S. |
| % FVC (±SD) | 74.7 (±29.1) | 73.7 (±22.5) | N.S. |
| FEV1.0 (±SD) | 2.21 (±1.33) | 1.71 (±0.71) | N.S. |
| FEV1.0% (±SD) | 88.8 (±8.4) | 79.4 (±9.2) | N.S. |
| % FEV1.0 (±SD) | 85.7 (±39.1) | 72.5 (±18.2) | N.S. |
| DLCO/VA (±SD) | 3.01 (±1.24) | 2.72 (±0.68) | N.S. |
| % DLCO/VA (±SD) | 70.8 (±30.3) | 63.3 (±17.2) | N.S. |
| Brinkman index (±SD) | 276 (±240) | 560 (±743) | N.S. |
| Prednisolone use before acute exacerbation (%) | 2 (66) | 9 (34) | N.S |
| PaO2/FIO2 ratio (±SD) | 148 (±124) | 222 (±103) | 0.26 |
| Days of antibiotic use (±SD) | 12.6 (±0.5) | 8.4 (±2.7) | 0.01 |
| Hospitalization days (±SD) | 43 (±17.4) | 27 (±15.4) | 0.10 |
| Death (%) | 1 (33) | 9 (34) | N.S. |
SD, standard deviation; BMI, body mass index; WBC, white blood cell; CRP, C-reactive protein; LDH, lactate dehydrogenase; KL-6, Krebs von den Lungen-6; FVC, forced vital capacity; FEV1.0, forced expiratory volume in 1 s; DLCO, diffusing capacity of carbon monoxide; DLCO/VA, DLCO corrected for alveolar volume; OCS, oral corticosteroid; PaO2/FIO2 ratio, the ratio of arterial oxygen partial pressure (PaO2) to fractional inspired oxygen (FIO2); N.S., not significant.