Table 5.
Pharmacokinetic parameters of 6-O-demethylmenisporphine after a single dose of intragastric administration (1.0 mg/kg) or intravenous injection (0.1 mg/kg) in rats (n = 6).
| Parameters | Intragastric (Mean ± SD) | Intravenous (Mean ± SD) |
|---|---|---|
| Cmax (μg/L) | 2201.24 ± 412.34 | 1556.36 ± 450.21 |
| Tmax (h) | 2.80 ± 0.84 | 0.10 ± 0.03 |
| t1/2z (h) | 5.10 ± 2.91 | 4.52 ± 1.09 |
| AUC0-t (μg/L*h) | 21215.89 ± 6310.61 | 4117.86 ± 1032.26 |
| AUC0-∞ (μg/L*h) | 21506.06 ± 6017.22 | 4201.20 ± 1027.83 |
| CLz (L/h/kg) | – | 0.025 ± 0.01 |
| CLz/F (L/h/kg) | 0.05 ± 0.01 | – |
| MRT0-t (h) | 7.82 ± 2.15 | 4.71 ± 0.48 |
| MRT0-∞ (h) | 8.13 ± 1.92 | 5.28 ± 0.99 |
| Bioavailability (%) | 51.52% |
Cmax: maximum plasma concentration; Tmax: time to Cmax; t1/2: half-life; AUC0-t: area under the curve from 0 to last time; AUC0-∞: area under the curve from 0 to infinite time; CLz/F: apparent oral clearance; MRT: mean residence time.