Table 5.

Description of Histotypes and Special Characteristics of the Three Human Colorectal Cancer Cell Lines Involved in the Investigation of the Biological Activity of Triazolo[3,4-b]thiadiazole Derivatives KA25, KA26, and KA39

Cancer Type	Human Cell Line Designation	p53 Status	MSI Status	References
Colorectal adenocarcinoma, Dukes’ type C	DLD-1	p. S241F	MSI-H (MSH6 deficiency)	46,47
Colorectal adenocarcinoma	HT-29	p. R273H	MSS	46,47
Colorectal adenocarcinoma, Duke’s type C, grade IV	LoVo	Wild type	MSI-H (MSH2 deficiency)	46,47

Abbreviations: MSI-H, Microsatellite instability; MSS, Microsatellite stable.