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Gradients of the Distance to Bound Configuration (DBC) coordinate for a phenol molecule bound to T4 lysozyme. The reference pose of phenol heavy atoms is shown in light cyan. The arrows are proportional to the derivatives of the CV with respect to atomic Cartesian coordinates. The small gradient contributions on protein Cα carbons illustrate the purely roto-translational counter-forces exerted on the receptor when biasing forces are applied to a DBC coordinate.
