Figure 1:

Effect of site-specific imaging protocol on PRM. Presented are representative axial slices from CT scans acquired at (A) inspiration, (B) expiration, (C) PRM overlay and (D) corresponding PRM scatter plot. from an individual case at each participating site. Peak voltage, tube current, slice thickness and slice number/arrangement varied between cases. For the inspiration CT scan protocol parameters were: (KI) 120 kVp, 249 mA, 0.6 mm, 708/contiguous; (FH) 120 kVp, 410 mA, 1.25 mm, 122/contiguous; and (UM) 120 kVp, 372 mA, 1.25 mm, 521/contiguous. For the expiration CT scan protocol parameters were: (KI) 120 kVp, 66 mA, 0.6 mm, 635/contiguous; (FH) 120 kVp, 180 mA, 1.25 mm, 12/incremental; and (UM) 120 kVp, 376 mA, 1.25 mm, 502/contiguous. PRM-derived values over the whole lung are provided within an insert above each PRM image. The green value and markers represent normal parenchyma, yellow value and markers represent fSAD (i.e. BOS) and magenta value and markers represent parenchymal disease. Age, gender and percent predicted values of FEV1 and FVC for each case were: (KI) 63 yrs, male, 40% and 62%; (FH) 57 yrs, male, 71% and 94%; and (UM) 68 yrs, male, 44% and 71%.