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. Author manuscript; available in PMC: 2021 Aug 3.
Published in final edited form as: Angew Chem Int Ed Engl. 2020 Jun 5;59(32):13575–13580. doi: 10.1002/anie.202004991

Table 2.

Evaluation of PKS TE hybrid modules with 2.[a]

graphic file with name nihms-1599899-t0013.jpg
Module TE Conversion to 6 (%) Conversion to 7 (%)
graphic file with name nihms-1599899-t0014.jpg graphic file with name nihms-1599899-t0010.jpg trace 34 ± 4.0
graphic file with name nihms-1599899-t0011.jpg ND 9.6 ± 1.0
graphic file with name nihms-1599899-t0012.jpg 22 ± 0.7 3.5 ± 0.1
graphic file with name nihms-1599899-t0015.jpg graphic file with name nihms-1599899-t0010.jpg ND trace
graphic file with name nihms-1599899-t0011.jpg ND ND
graphic file with name nihms-1599899-t0012.jpg trace ND
graphic file with name nihms-1599899-t0016.jpg graphic file with name nihms-1599899-t0010.jpg trace ND
graphic file with name nihms-1599899-t0011.jpg ND ND
graphic file with name nihms-1599899-t0012.jpg 24 ± 0.7 ND
[a]

Substrate 2 is generated by in situ photolysis of the 2-nitrobenzyloxymethyl ether (NBOM) protected native hexaketide.4b Conversion to 6 or 7 was monitored by HPLC with data represented as the mean ± standard deviation where n = 3. Trace = detected by LC-MS but below the detection limit of HPLC. ND = not detected.