Table 1.
Study Author, Year | Region* | Level of Evidence† | Study Quality‡ | IUD Type§ | Placement Timing∥ |
Delivery Type¶ | Length of Follow-up | Number Enrolled or Randomized | Number of Women with lUDs Placed | Number of Women with IUDs Placed with Follow-up (%) |
---|---|---|---|---|---|---|---|---|---|---|
Agarwal, 201745 | S.E. Asia | II-3 | Fair | CuT380A | Immediate | Cesarean | 3 months | 50 | 50 | 50 (100) |
Baldwin, 201637 | N. America | I | Fair | Mixed | Mixed | Mixed | 6 months | 201 | 139 | unknown (66#) |
Blumenthal, 201824 | S.E. Asia | II-3 | Good | CuT380A | Mixed | Vaginal | 6 weeks | 500 | 496 | 480 (97) |
Braniff, 201540 | W. Pacific | I | Fair | LNG-IUD | Mixed | Cesarean | 6 months | 48 | 42 | unknown (84#) |
Bryant, 201332 | Africa | I | Poor | CuT380A | Mixed | Vaginal | 12 weeks | 49 | 28 | 28 (100) |
Celen, 201129 | E. Mediterranean | II-3 | Good | CuT380A | Immediate | Cesarean | 12 months | 245 | 245 | 245 (100) |
Chen, 201030 | N. America | I | Good | LNG-IUD | Mixed | Vaginal | 6 months | 124 | 96 | 84 (88) |
Chen, 201738 | N. America | II-2 | Poor | Mixed | Mixed | Mixed | 6 months | 74 | 74 | 59 (80) |
Cohen, 201666 | N. America | II-3 | Poor | Mixed | Immediate | Mixed | 12 months | 82 | 82 | 67 (82) |
Cole, 201925 | N. America | II-3 | Poor | LNG-IUD | Immediate | Mixed | 6 months | 116 | 116 | 87 (75) |
Colwill, 201846 | N. America | II-2 | Fair | CuT380A | Immediate | Mixed | 6 weeks | 210 | 210 | 169 (80) |
Dahlke, 201133 | N. America | I | Poor | LNG-IUD | Mixed | Vaginal | 6 months | 53 | 46 | 45 (98) |
Dias, 201547 | S.E. Asia | II-2 | Poor | CuT380A | Immediate | Mixed | 6 weeks | 91 | 91 | 91 (100) |
Eggebroten, 201767 | N. America | II-2 | Poor | Mixed | Immediate | Mixed | 6 months | 211 | 211 | 186 (88) |
Elsedeek, 201262 | E. Mediterranean | II-3 | Fair | LNG-IUD | Immediate | Cesarean | 2 years | 65 | 65 | 62 (95) |
Elsedeek, 201563 | E. Mediterranean | II-3 | Fair | LNG-IUD | Immediate | Cesarean | 5 years | 80 | 80 | 80 (100) |
Eroglu, 200634 | E. Mediterranean | II-2 | Fair | CuT380A | Mixed | Vaginal | 12 months | 268 | 268 | 257 (96) |
Goldthwaite, 201768 | N. America | II-2 | Fair | Mixed | Immediate | Vaginal | 12 weeks | 123 | 123 | 96 (78) |
Gueye, 201348 | Africa | II-3 | Fair | CuT380A | Immediate | Cesarean | 6 months | 46 | 46 | 39 (85) |
Gupta, 201461 | S.E. Asia | II-3 | Fair | CuT380A | Immediate | Mixed | 6 months | 100 | 100 | 92 (92) |
Gurney, 201826 | N. America | II-3 | Good | CuT380A | Immediate | Vaginal | 6 months | 200 | 195 | 162 (83) |
Hayes, 200764 | N. America | II-3 | Fair | LNG-IUD | Immediate | Vaginal | 10 weeks | 20 | 20 | 16 (80) |
Heller, 201669 | Europe | II-3 | Fair | Mixed | Immediate | Cesarean | 12 months | 120 | 114 | 99 (87) |
Hinz, 201927 | N. America | II-3 | Fair | Mixed | Immediate | Mixed | 6 months | 118 | 118 | 114 (97) |
Hooda, 201649 | S.E. Asia | II-2 | Poor | CuT380A | Immediate | Mixed | 6 weeks | 593 | 593 | 171 (29) |
Jatlaoui, 201470 | N. America | II-3 | Fair | Mixed | Immediate | Vaginal | 6 months | 99 | 99 | 88 (89) |
Kumar, 201928 | S.E. Asia | II-3 | Poor | CuT380A | Mixed | Mixed | 12 months | 1200 | 1200 | 844 (70) |
Kumar, 201450 | S.E. Asia | II-3 | Poor | CuT380A | Mixed | Mixed | 6 weeks | 2733 | 2733 | 1730 (63) |
Lester, 201541 | Africa | I | Poor | CuT380A | Mixed | Cesarean | 6 months | 68 | 52 | unknown (90#) |
Letti Muller, 200551 | S. America | II-2 | Fair | CuT380A | Immediate | Mixed | 1 month | 38 | 38 | 37 (97) |
Levi, 201252 | N. America | II-3 | Fair | CuT380A | Immediate | Cesarean | 6 months | 90 | 90 | 42 (47) |
Levi, 201531 | N. America | I | Good | Mixed | Mixed | Cesarean | 6 months | 112 | 87 | unknown (88#) |
Mishra, 201453 | S.E. Asia | II-3 | Poor | CuT380A | Immediate | Mixed | 4–6 weeks | 564 | 564 | 434 (77) |
Nelson, 200954 | N. America | II-3 | Fair | CuT380A | Immediate | Cesarean | 6 weeks | 7 | 7 | 7 (100) |
Puzey, 200565 | Africa | II-3 | Poor | LNG-IUD | Immediate | Cesarean | 6 months | 33 | 33 | 20 (61) |
Ragab, 201555 | E. Mediterranean | II-3 | Fair | CuT380A | Immediate | Cesarean | 12 months | 40 | 40 | 40 (100) |
Singal, 201454 | S.E. Asia | II-3 | Fair | CuT380A | Immediate | Cesarean | 12 months | 300 | 300 | 300 (100) |
Singh, 201657 | S.E. Asia | II-3 | Fair | CuT380A | Mixed | Vaginal | 8 weeks | 80 | 80 | 80 (100) |
Soon, 201843 | N. America | I | Poor | LNG-IUD | Mixed | Vaginal | 6 months | 11 | 8 | 7 (88) |
Stuart, 201236 | N. America | II-3 | Fair | LNG-IUD | Early | Vaginal | 6 months | 40 | 29 | 27 (93) |
Stuart, 201535 | N. America | I | Poor | LNG-IUD | Mixed | Vaginal | 6 months | 35 | 31 | unknown (80#) |
Sucak, 201558 | E. Mediterranean | II-2 | Fair | CuT380A | Immediate | Mixed | 12 months | 160 | 160 | 153 (96) |
Turok, 201744 | N. America | I | Poor | LNG-IUD | Mixed | Mixed | 8 weeks | 285 | 228 | 214 (94) |
Unal, 201860 | E. Mediterranean | II-3 | Fair | CuT380A | Immediate | Cesarean | 3 months | 70 | 70 | 68 (97) |
Whitaker, 201442 | N. America | I | Poor | LNG-IUD | Mixed | Cesarean | 12 months | 42 | 37 | unknown (81#) |
Woo, 201571 | N. America | II-3 | Poor | Mixed | Immediate | Mixed | 12 months | 76 | 76 | 43 (57) |
Xu, 199959 | W. Pacific | II-3 | Fair | CuT380A | Immediate | Vaginal | 36 months | 384 | 384 | 381 (99) |
Zerden, 201739 | N. America | II-3 | Fair | LNG-IUD | Delayed | Mixed | 6 months | 50 | 50 | 43 (86) |
Abbreviations: Cu= copper; IUD= intrauterine device; LNG= levonorgestrel
Based on World Health Organization (WHO) Regions with Region of the Americas separated into North and South American regions.
Level of evidence: I, a randomized, controlled trial; II-2, a cohort or case-controlled study that includes a comparison group; II-3, an uncontrolled descriptive study including case series.
Defined by U.S. Preventive Services Task Force (Harris RP, Helfand M, Woolf SH, et al. Current methods of the US Preventive Services Task Force: a review of the process. Am J Prev Med 2001; 20:21–35)
Mixed=CuT380A and LNG IUD combined
Immediate = ≤10 minutes of placental delivery; Early = >10 minutes to <4 weeks postpartum; Mixed = Immediate and early placements; or, immediate or early placements and interval placements (≥ 4 weeks postpartum)
Mixed=vaginal or cesarean delivery
Number of women with IUDs placed having follow-up not reported, therefore percentage represents number of women with IUD placements among all women randomized.