Table 2.

Initial triage filters applied to the list of statistical signals

Scope	Description
International reporting	Include only DDA combinations with reports from at least two countries in VigiBase–reflecting the international focus of the WHO Programme for International Drug Monitoring
Recent report(s)	Include only DDA combinations with at least one report entered into VigiBase after 31 August 2014–focusing on recent topics
Serious adverse events	Include only DDA combinations for which either (1) the adverse event is included on the European Medicine Agency’s list of important medical events; or (2) at least 75% of the E2B reports in the case series are classified as serious–focusing on adverse events with significant clinical impact

DDA drug–drug adverse event