Table 3.

Secondary triage filters applied to the list of statistical signals

Scope	Description
Previously checked	Exclude DDA combinations that have been previously assessed by Uppsala Monitoring Centre for a possible interaction
Listed in Stockley’s	Exclude DDA combinations where the drug pair is identified as already listed to interact in Stockley's with the natural language processing methods outlined above
Listed in Janusmed	Exclude DDA combinations where the drug pair is listed to interact in Janusmed interactions (class C or D AND grade 2–4)
Adverse event listed for both drugs	Exclude DDA combinations where the adverse event is identified as known for both drugs using Uppsala Monitoring Centre’s algorithms for natural language processing of literature sources
Adverse event is ‘drug interaction’	Exclude DDA combinations where the adverse event is the MedDRA Preferred Term ‘drug interaction’. This term is included in the algorithm and is thus overrepresented in the combinations list. Combinations with this term, assessed at the pre-evaluation, were already known interactions
Adverse events related to product quality or use	Exclude DDA combinations where the adverse events relate to product quality (MedDRA High Level Term ‘product quality issues NEC’) or product use (High Level Term ‘product use issues NEC’, as well as the individual Preferred Terms ‘off-label use’, ‘labelled drug–drug interaction medication error’, ‘medication error’, ‘medication residue present’, or ‘intentional overdose’)

DDA drug–drug adverse event, MedDRA Medical Dictionary for Regulatory Activities, NEC not elsewhere classified