Table 2.

Barriers to inclusion

Barrier
Barriers relating to physical disability
Difficulties in consenting for another person
Feeling unqualified to take part (e.g. due to lack of education)
Lack of available trials/poor trial promotion
Lack of effective incentives for participation
Lack of interest in research
Lack of trust in trials
Negative attitudes to the concept of research
Negative financial impact
Potential participants refusing to accept their health condition
Poor consent procedures
Requirement for additional carer time to aid participant
Participant risk perception
Specific cultural barriers
Specific health fears (e.g. hospitals, needles)
Treatment centres not set up for research
Trials asking too much for participation
Unwilling to receive placebo