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. 2020 Jul 22;2020:4603169. doi: 10.1155/2020/4603169

Table 4.

Literature review of coronary physiology before versus after treatment of severe aortic stenosis.

Authors Citation N Baseline Immediate p value Long term p value Time Treatment Method
Resting perfusion (cc/min/g) or Doppler velocity (cm/sec)
Nemes et al. [28] Herz 2002; 27: 780 21 62.2 40.1 <0.01 15 months SAVR Echo Doppler (diastolic)
Hildick-Smith and Shapiro [44] JACC 2000; 36: 1889 27 43 41 NS 6 months SAVR Echo Doppler (diastolic)
Carpeggiani et al. [24] J CV Med 2008; 9: 893 8 1.01 0.92 >0.05 12 months SAVR PET
Rajappan et al. [70] Circulation 2003; 107: 3170 22 1.08 1.01 0.27 12 months SAVR PET
Camuglia et al. [34] JACC 2014; 63: 1808 8 22 20 NS 18 NS 12 months TAVI Wire (Doppler)
Vendrik et al. [35] JAHA 2020; pending 13 19.98 19.7 NS 21.44 0.397 6 months TAVI Wire (Doppler)
Ahmad et al. [37] JACC CV Int 2018; 11: 2019 30 22.13 24.84 0.1 TAVI Wire (Doppler)
Wiegerinck et al. [36] Circ CV Int 2015; 8: e002443 27 24.4 25.5 0.401 TAVI Wire (Doppler)
Instantaneous wave-free ratio (iFR)
Vendrik et al. [35] JAHA 2020; pending 13 0.82 0.83 NS 0.83 0.735 6 months TAVI
Ahmad et al. [37] JACC CV Int 2018; 11: 2019 30 0.88 0.88 0.94 TAVI
Scarsini et al. [38] EuroIntervention 2018; 13: 1512 145 0.89 0.89 0.66 TAVI
Hyperemic perfusion (cc/min/g) or Doppler velocity (cm/sec) or mean transit time (sec)
Nemes et al. [28] Herz 2002; 27: 780 21 117 91.5 <0.05 15 months SAVR Echo Doppler (diastolic)
Hildick-Smith and Shapiro [44] JACC 2000; 36: 1889 27 71 108 <0.01 6 months SAVR Echo Doppler (diastolic)
Carpeggiani et al. [24] J CV Med 2008; 9: 893 8 1.68 1.46 NS 12 months SAVR PET
Rajappan et al. [27] Circulation 2003; 107: 3170 22 2.17 2.27 0.61 12 months SAVR PET
Camuglia et al. [34] JACC 2014; 63: 1808 8 34 29 NS 39 NS 12 months TAVI Wire (Doppler)
Vendrik et al. [35] JAHA 2020; pending 13 26.36 30.78 <0.001 40.2 <0.001 6 months TAVI Wire (Doppler)
Wiegerinck et al. [36] Circ CV Int 2015; 8: e002443 27 44.5 51.1 0.027 TAVI Wire (Doppler)
Ahmad et al. [37] JACC CV Int 2018; 11: 2019 30 33.44 40.33 0.004 TAVI Wire (Doppler)
Stoller et al. [48] EuroIntervention 2018; 14: 166 40 0.44 0.48 0.53 TAVI Wire (thermo)
Coronary flow reserve (CFR)
Nemes et al. [32] Herz 2002; 27: 780 21 1.96 2.37 <0.05 15 months SAVR Echo Doppler (diastolic)
Hildick-Smith and Shapiro [44] JACC 2000; 36: 1889 27 1.76 2.61 <0.01 6 months SAVR Echo Doppler (diastolic)
Carpeggiani et al. [24] J CV Med 2008; 9: 893 8 1.68 1.58 NS 12 months SAVR PET
Rajappan et al. [70] Circulation 2003; 107: 3170 22 2.02 2.28 0.17 12 months SAVR PET
Camuglia et al. [34] JACC 2014; 63: 1808 8 1.53 1.58 0.41 2.18 <0.01 12 months TAVI Wire (Doppler)
Vendrik et al. [35] JAHA 2020; pending 13 1.28 1.65 <0.001 1.94 <0.001 6 months TAVI Wire (Doppler)
Wiegerinck et al. [36] Circ CV Int 2015; 8: e002443 27 1.9 2.1 0.113 TAVI Wire (Doppler)
Stoller et al. [48] EuroIntervention 2018; 14: 166 40 1.9 2 0.72 TAVI Wire (thermo)
Fractional flow reserve (FFR)
Stundl et al. [41] Clin Res Cardiol 2019; Epub 13 0.77 0.76 0.11 2 months TAVI
Vendrik et al. [35] JAHA 2020; pending 13 0.85 0.79 <0.001 0.71 <0.001 6 months TAVI
Ahmad et al. [37] JACC CV Int 2018; 11: 2019 30 0.87 0.85 0.0008 TAVI
Stoller et al. [48] EuroIntervention 2018; 14: 166 40 0.9 0.93 0.0021 TAVI
Pesarini et al. [71] Circ CV Int 2016; 9: e004088 133 0.89 0.89 0.73 TAVI

NS = not significant (actual p value not reported), PET = positron emission tomography, SAVR = surgical aortic valve replacement, TAVI = transcatheter aortic valve implantation, and thermo = bolus thermodilution (based on the table from 2020 editorial [68]).