Skip to main content
. 2020 Jul 24;2020:6437057. doi: 10.1155/2020/6437057

Figure 1.

Figure 1

Signaling pathways of inhibitory receptors in NK cells. After KIR2DL, KIR3DL, and CD49/NKG2A bind to their corresponding ligands, the ITIM sequences are phosphorylated by Src-family kinase (SFK). Furthermore, the phosphorylated ITIM recruits SHP-1/SHP-2, which downregulates the phosphorylation level of the downstream signaling molecules (XX/YY) of activating receptors, including Vav1, thereby inhibiting NK cell function. In addition, Crk binds to Abl and is phosphorylated by Abl, which separates Crk from the Cbl-Crk-C3G complex, further inhibiting NK cell function.