Table 2.
Association between baseline serum uric acid and risk of type 2 diabetes mellitus.
| Person-year | Incident diabetes | Incidence (per 1,000 person-years) | Model 1† | Model 2‡ | Model 3§ | ||
|---|---|---|---|---|---|---|---|
| Men | |||||||
| Q1 | 19,509 | 300 | 15.38 | 1.00 | 1.00 | 1.00 | |
| Q2 | 20,080 | 334 | 16.63 | 1.13 (0.97-1.32) | 1.05 (0.87-1.27) | 1.09 (0.90-1.31) | |
| Q3 | 19,738 | 362 | 18.34 | 1.21 (1.04-1.41) | 1.01 (0.84-1.22) | 1.04 (0.87-1.26) | |
| Q4 | 19,449 | 441 | 22.67 | 1.54 (1.33-1.78) | 1.12 (0.93-1.35) | 1.11 (0.92-1.34) | |
| Ptrend | <0.001 | 0.249 | 0.371 | ||||
| Hyperuricemia | 20,941 | 479 | 22.87 | 1.41 (1.27-1.58) | 1.12 (0.98-1.29) | 1.06 (0.92-1.22) | |
| SUA (per 1-mg/dL) | 78,776 | 1,678 | 21.30 | 1.14 (1.10-1.19) | 1.04 (0.98-1.09) | 1.04 (0.99-1.10) | |
| Women | |||||||
| Q1 | 13,193 | 48 | 3.64 | 1.00 | 1.00 | 1.00 | |
| Q2 | 13,151 | 62 | 4.71 | 1.21 (0.83-1.76) | 1.03 (0.65-1.65) | 1.00 (0.62-1.61) | |
| Q3 | 13,424 | 125 | 9.31 | 2.10 (1.50-2.94) | 1.70 (1.12-2.58) | 1.78 (1.17-2.71) | |
| Q4 | 13,868 | 270 | 19.47 | 3.37 (2.46-4.62) | 2.14 (1.43-3.22) | 1.93 (1.27-2.93) | |
| Ptrend | <0.001 | <0.001 | <0.001 | ||||
| Hyperuricemia | 3,906 | 120 | 30.72 | 2.40 (1.94-2.97) | 1.82 (1.38-2.40) | 1.35 (1.01-1.80) | |
| SUA (per 1-mg/dL) | 53,637 | 585 | 10.91 | 1.55 (1.44-1.68) | 1.31 (1.17-1.45) | 1.20 (1.08-1.34) |
Abbreviations: BMI: body mass index; WC: waist circumference; SUA: serum uric acid; FPG: fasting plasma glucose; TC: total cholesterol; TG: triglycerides; HDL-C: high-density lipoprotein cholesterol; eGFR: estimated glomerular filtration rate; ALT: alanine aminotransferase. Data are hazard ratios (HRs) (95% confidence intervals (CIs)). †Model 1: adjusted for age at baseline. ‡Model 2: adjusted for age, BMI, WC, heart rate, systolic blood pressure, and levels of TC, TG, HDL-C, eGFR, ALT, and white blood cell count at baseline. §Model 3: adjusted for FPG level at baseline, plus all variables in model 2.