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. 2020 Jul 23;2020:6538930. doi: 10.1155/2020/6538930

Figure 9.

Figure 9

Brief summary of the mechanism of andrographolide on diabetes. This study demonstrated that andrographolide ameliorated glucose intolerance and insulin resistance in db/db diabetic mice. Andrographolide exerted glucose-lowering effect through strengthening intestinal barrier function and increasing microbial composition of A. muciniphila, which illuminates a plausible approach to ameliorate T2D.