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. 2020 Aug 2;56(4):106129. doi: 10.1016/j.ijantimicag.2020.106129

Table 1.

Baseline characteristics of patients with COVID-19 according to periods of hospitalization.

Characteristics at baseline In first period In second period P-value
N= 40 N= 92
Age (year) — mean ± SD 62.17 ± 15.24 57.59 ± 16.64 0.13
Sex (M) — no. (%) 26 (58) 59 (64) 0.99
Obesity — no. (%) 2 (4) 13 (14) 0.22
Smoking (yes) — no. (%) 13 (29) 16 (17) 0.09
CCI* — no. (%)
 0 4 (10) 20 (22) 0.38
 1-2 14 (35) 33 (36)
 3-4 11 (28) 20 (22)
 ≥5 11 (28) 19 (21)
Pulmonary CT scan — no. (%) 20 (50) 83 (90) <0.0001
 Normal 2 (10) 5 (6) 0.46
 Limited 6 (30) 11 (13)
 Mild 0 (0) 24 (29)
 Moderate 9 (45) 32 (39)
 Severe 3 (15) 11 (13)
Lymphocyte count <1000/mm3 — no. (%) 17 (42) 54 (59) 0.13
PMN count >8000/mm3 5 (13) 9 (10) 0.64
CRP mg/L — mean ± SD 84.59 ± 70.31 83.70 ± 71.86 0.95
Oxygen (yes) — no. (%) 21 (53) 74 (80) 0.001
 ≤2L/min 10 (48) 38 (51) 0.55
 2 – 5 L/min 10 (48) 27 (36)
 >5 L/min 1 (5) 9 (12)
Treatment strategies — no. (%)
 No treatment 30 (75) 22 (24) <0.0001
 AZI ± HCQ 10 (25) 70 (76)

In first period is defined as 03/05 to 03/19

In second period is defined as 03/20 to 04/25; AZI, Azithromycin; HCQ, Hydroxychloroquine; N, number; %, percent; SD, standard deviation; M, men; Obesity with body mass index ≥30 kg/m²

CCI, Charlson Comorbidity Index; PMN, polymorphonuclear leukocyte; CRP, C-reactive protein; CT, computerized tomography; pulmonary CT scan category normal 0%, limited <10%, mild 10–25%, moderate 25–50%, severe >50%; a Student test (equal variance) or Welche-Satterthwaite t test (unequal variance) was used to analyse quantitative variables, a Mantel-Haenszel Chi-Square test was used to analyse the qualitative variables and the exact test of Fisher was used when the sample sizes were small (<5). Test significant (P<0.05).