Table 2.

Potential factors associated with unfavorable outcome: Cox model regression.

Variables	n/N	Univariate model			Multivariate model 1			Multivariate model 2
		HR [IC95%]	P-value		HR [IC95%]	P-value		HR [IC95%]	P-value
					Adjusted on ICC, obesity, O2, lymphocyte count and treatments			Adjusted on ICC, obesity, O2 CRP and treatments
Characteristics at baseline
Age (years)	132/132	1.02 [1.00 – 1.05]	0.07		-	-		-	-
Sex (M)	85/132	0.86 [0.40 – 1.85]	0.71		-	-		-	-
Obesity (yes)	15/132	0.27 [0.04 – 1.98]	0.20		0.47 [0.06- 3.63]	0.47		0.44 [0.06 – 3.45]	0.43
Smoking (yes)	29/132	1.00 [0.41 - 2.48]	0.99		-	-		-	-
CCI*
0	24/132	1*	-		1*	-		1	-
1-2	47/132	0.88 [0.26 - 3.00]	0.83		1.05 [0.29 – 3.87]	0.47		1.10 [0.31 – 3.92]	0.89
3-4	31/132	1.88 [0.58 – 6.12]	0.29	0.39	1.30 [0.37 – 4.54]	0.68	0.97	1.74 [0.52 – 5.81]	0.37	0.73
≥5	30/132	1.63 [0.49 – 5.43]	0.42		1.10 [0.32 – 3.75]	0.87		1.08 [0.32 – 3.71]	0.90
PMN count ≥8000/mm3	14/132	1.42 [0.49 – 4.10]	0.52		-	-		-	-
Lymphocyte count <1000/mm3	71/132	4.91 [1.99 – 12.1]	0.0006		4.90 [1.95 – 12.3]	0.0007		-	-
CRP ≥100 mg/L	85/132	2.86 [1.35 – 6.05]	0.006		-	-		2.78 [1.00 – 5.23]	0.05
Treatment strategies
Oxygen (L/min)		1.20 [1.10 - 1.31]	<0.0001		1.25 [1.13 – 1.38]	<0.0001		1.20 [1.08 - 1.32]	0.0005
No treatment and	52/132	1*	-		1*	-		1*	-
AZI ± HCQ	80/132	0.63 [0.30 – 1.23]	0.23		0.45 [0.21 – 0.97]	0.04		0.42 [0.18 – 0.95]	0.04

n/N number/total; 1* indicates the reference category; HR, Hazard ratio; CI, confidence interval; NS, not significant (P>0.05); PMN, polymorphonuclear; *CCI, The Charlson Comorbidity Index; CRP, C-Reactive protein; AZI, Azithromycin; HCQ, Hydroxychloroquine; No treatment defined as patients who have had no treatment or lopinavir-ritonavir; Multivariate Cox model regression was used to identify the potential factors associated with unfavorable outcome (ICU admission or death after ICU), adjusted on CCI (including age), obesity, oxygen and treatment strategies groups according to CRP.