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. 2020 Aug 2;130:104572. doi: 10.1016/j.jcv.2020.104572

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© 2020 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 5 — Percentage inhibition by anti-SARS-CoV-2 S and RBD antibody measured by MSD pseudo-neutralisation assay.

Inhibition of ACE-2 binding by SARS-CoV-2 antibody against (a) spike (S) and (b) receptor binding domain (RBD) was measured using the MSD coronavirus pseudo-neutralisation assay. 183 COVID-19 cohort samples and 194 control samples were analysed. Graphs show median and 95 % CI with a line showing neutralisation assay positive/negative discrimination cut-off determined by ROC. The correlation between antibody concentration and percentage inhibition of (c) S and (d) RBD antigens in all positive group samples was assessed and r and p was determined by Spearman correlation, line shows binding assay positive/negative discrimination cut-off.