Table 1. Clinical and demographic characteristics of GC patients in CIMP-related subgroups.

	CIMP-L	CIMP-M	CIMP-H	p-Value
Number of patients	179	128	88
Age (Mean (SD))	64.3 (10.5)	65.6 (10.5)	66.4 (11.3)	0.191
Gender				0.194
Female	70 (39.1%)	38 (29.7%)	28 (31.8%)
Male	109 (60.9%)	90 (70.3%)	60 (68.2%)
Pathologic_T				0.724
T1	7 (3.9%)	7 (5.5%)	7 (8.0%)
T2	39 (21.8%)	24 (18.8%)	15 (17.0%)
T3	85 (47.5%)	63 (49.2%)	38 (43.2%)
T4	48 (26.8%)	34 (26.6%)	28 (31.8%)
Pathologic_N				0.044
N0	51 (28.5%)	36 (28.1%)	37 (42.6%)
N1	49 (27.4%)	31 (24.2%)	22 (25.3%)
N2	36 (20.1%)	34 (26.6%)	9 (10.3%)
N3	38 (21.2%)	27 (21.1%)	18 (20.7%)
NX	5 (2.8%)	0 (0%)	1 (1.1%)
Pathologic_M				0.115
M0	155 (86.6%)	115 (89.8%)	83 (94.3%)
M1	11 (6.1%)	10 (7.8%)	2 (2.3%)
MX	13 (7.3%)	3 (2.3%)	3 (3.4%)
Pathologic_Stage				0.225
Stage I	23 (12.8%)	14 (10.9%)	16 (18.2%)
Stage II	58 (32.4%)	42 (32.8%)	32 (36.4%)
Stage III	78 (43.6%)	59 (46.1%)	38 (43.2%)
Stage IV	20 (11.2%)	13 (10.2%)	2 (2.3%)
Lauren.Class				0.112
Diffuse	49 (27.4%)	36 (28.1%)	18 (20.5%)
Intestinal	115 (64.2%)	71 (55.5%)	61 (69.3%)
Mixed	15 (8.4%)	21 (16.4%)	9 (10.2%)
Grade				0.264
G1	4 (2.2%)	3 (2.3%)	2 (2.3%)
G2	76 (42.5%)	41 (32.0%)	25 (28.4%)
G3	94 (52.5%)	81 (63.3%)	60 (68.2%)
GX	5 (2.8%)	3 (2.3%)	1 (1.1%)
H. pylori infection				0.779
No	79 (87.8%)	56 (90.3%)	33 (91.7%)
Yes	11 (12.2%)	6 (9.7%)	3 (8.3%)
MSI.status				<0.001
MSI-H	4 (4.0%)	11 (14.4%)	34 (47.9%)
MSI-L	11 (10.9%)	18 (23.7%)	8 (11.3%)
MSS	86 (85.1%)	47 (61.9%)	29 (40.8%)
EBV.positive				<0.001
Negative	101 (100%)	76 (100%)	46 (64.8%)
Positive	0 (0%)	0 (0%)	25 (35.2%)