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. Author manuscript; available in PMC: 2020 Aug 2.
Published in final edited form as: Cell Rep. 2020 Jul 7;32(1):107874. doi: 10.1016/j.celrep.2020.107874

Figure 5. Maternal-Fetal Obstetrical Parameters upon Partial or Total Treg Depletion.

Figure 5.

(A) Foxp3DTR dams underwent partial or total Treg depletion until 17.5 dpc on which body temperature, blood pressure, and Doppler determinations were performed (n = 8–9 per group).

(B and C) Body temperature (B) and mean blood pressure (C) of non-Treg-depleted-, partially Treg-depleted-, and totally Treg-depleted-Foxp3DTR dams (n = 8–9 per group).

(D–F) Representative Doppler image of the uterine artery (D), which was used to determine (E) maternal heart rate, and (F) uterine artery pulsatility index of non-Treg-depleted-, partially Treg-depleted-, and totally Treg-depleted-Foxp3DTR dams (n = 8–9 per group).

(G–I) Representative Doppler image of the umbilical artery (G), which was used to determine (H) fetal heart rate, and (I) umbilical artery pulsatility index in fetuses of non-Treg-depleted-, partially Treg-depleted-, and totally Treg-depleted-Foxp3DTR dams (n = 24–27 per group).

(J) Representative images of the spleens and ULNs from non-Treg-depleted-, partially Treg-depleted-, and totally Treg-depleted-Foxp3DTR dams (n = 3 per group).

(K) Representative images of neonates born to non-Treg-depleted-, partially Treg-depleted-, and totally Treg-depleted-Foxp3DTR dams on the day of birth (n = 3 per group). Red dotted squares indicate the presence of the milk band. Statistical analysis was performed using the Kruskal-Wallis or ANOVA tests with correction for multiple comparisons.