Table 2.
Variables | ≤3 cycles post-operatively (n=41) | >3 cycles post-operatively (n=59) | P value |
---|---|---|---|
Treatment characteristics | |||
Regimen | |||
Carboplatin/paclitaxel every 21 or 28 days | 17 (41.5%) | 27 (45.8%) | 0.49 |
Carboplatin/weekly paclitaxel or docetaxel | 19 (46.3%) | 24 (40.7%) | |
Intraperitoneal chemotherapy | 4 (9.8%) | 5 (8.5%) | |
Other | 0 (0.0%) | 3 (5.3%) | |
Missing | 1 (2.4%) | 0 (0.0%) | |
Post-operative cycles (n) | |||
2 | 3 (7.3%) | N/A | <0.0001 |
3 | 38 (92.7%) | N/A | |
4 | N/A | 22 (37.3%) | |
5 | N/A | 10 (16.9%) | |
6 | N/A | 23 (39.0%) | |
7 | N/A | 3 (5.1%) | |
8 | N/A | 0 (0.0%) | |
9 | N/A | 1 (1.7%) | |
Median number of total treatment cycles | 6 | 8 | <0.0001 |
Granulocyte colony stimulating factor use | |||
Yes | 12 (29.3%) | 25 (42.4%) | 0.23 |
No | 20 (48.8%) | 19 (32.2%) | |
Missing | 9 (22.0%) | 14 (25.4%) | |
Dose delay ≥7 days | |||
Yes | 12 (29.3%) | 23 (39.0%) | 0.57 |
No | 20 (48.8%) | 23 (39.0%) | |
Missing | 9 (22.0%) | 13 (22.0%) | |
Dose reduction | |||
Yes | 12 (29.3%) | 16 (27.1%) | 0.54 |
No | 13 (31.7%) | 25 (42.4%) | |
Missing | 16 (39.0%) | 18 (30.5%) | |
Toxicities* | |||
Neutropenia | |||
Yes | 11 (26.8%) | 11 (18.6%) | 0.73 |
No | 18 (43.9%) | 28 (47.5%) | |
Missing | 12 (29.3%) | 20 (33.9%) | |
Thrombocytopenia | |||
Yes | 6 (14.6%) | 4 (6.8%) | 0.60 |
No | 23 (56.1%) | 35 (59.3%) | |
Missing | 12 (29.3%) | 20 (33.9%) | |
Anemia | |||
Yes | 4 (9.8%) | 9 (15.3%) | 0.68 |
No | 25 (61.0%) | 30 (50.8%) | |
Missing | 12 (29.3%) | 20 (33.9%) | |
Fatigue | |||
Yes | 6 (14.6%) | 8 (13.6%) | 0.75 |
No | 23 (56.1%) | 29 (49.2%) | |
Missing | 12 (29.3%) | 22 (37.3%) | |
Nausea/vomiting | |||
Yes | 1 (2.4%) | 7 (11.9%) | 0.22 |
No | 28 (68.3%) | 31 (52.5%) | |
Missing | 12 (29.3%) | 21 (35.6%) | |
Diarrhea | |||
Yes | 0 (0.0%) | 1 (1.7%) | 0.62 |
No | 29 (70.7%) | 36 (61.0%) | |
Missing | 12 (29.3%) | 22 (37.3%) | |
Neuropathy | |||
Yes | 5 (12.2%) | 16 (27.1%) | 0.23 |
No | 24 (58.5%) | 25 (42.4%) | |
Missing | 12 (29.3%) | 18 (30.5%) | |
Allergic reaction | |||
Yes | 1 (2.4%) | 0 (0.0%) | 0.50 |
No | 28 (68.3%) | 37 (62.7%) | |
Missing | 12 (29.3%) | 22 (37.3%) | |
Other† | |||
Yes | 4 (9.8%) | 10 (16.9%) | 0.58 |
No | 25 (61.0%) | 29 (49.2%) | |
Missing | 12 (29.3%) | 20 (33.9%) |
Values shown as n (%).
All toxicities grade 2 or higher.
Included acute kidney injury, anorexia, constipation, phlebitis, abdominal pain.
N/A, not applicable.