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. Author manuscript; available in PMC: 2020 Aug 2.
Published in final edited form as: Int J Gynecol Cancer. 2019 Jul 27;29(7):1156–1163. doi: 10.1136/ijgc-2019-000374

Table 2.

Post-operative chemotherapy treatment characteristics and toxicitiesCaption

Variables ≤3 cycles post-operatively (n=41) >3 cycles post-operatively (n=59) P value

Treatment characteristics
 Regimen
  Carboplatin/paclitaxel every 21 or 28 days 17 (41.5%) 27 (45.8%) 0.49
  Carboplatin/weekly paclitaxel or docetaxel 19 (46.3%) 24 (40.7%)
  Intraperitoneal chemotherapy 4 (9.8%) 5 (8.5%)
  Other 0 (0.0%) 3 (5.3%)
  Missing 1 (2.4%) 0 (0.0%)
 Post-operative cycles (n)
  2 3 (7.3%) N/A <0.0001
  3 38 (92.7%) N/A
  4 N/A 22 (37.3%)
  5 N/A 10 (16.9%)
  6 N/A 23 (39.0%)
  7 N/A 3 (5.1%)
  8 N/A 0 (0.0%)
  9 N/A 1 (1.7%)
 Median number of total treatment cycles 6 8 <0.0001
 Granulocyte colony stimulating factor use
  Yes 12 (29.3%) 25 (42.4%) 0.23
  No 20 (48.8%) 19 (32.2%)
  Missing 9 (22.0%) 14 (25.4%)
 Dose delay ≥7 days
  Yes 12 (29.3%) 23 (39.0%) 0.57
  No 20 (48.8%) 23 (39.0%)
  Missing 9 (22.0%) 13 (22.0%)
 Dose reduction
  Yes 12 (29.3%) 16 (27.1%) 0.54
  No 13 (31.7%) 25 (42.4%)
  Missing 16 (39.0%) 18 (30.5%)
Toxicities*
 Neutropenia
  Yes 11 (26.8%) 11 (18.6%) 0.73
  No 18 (43.9%) 28 (47.5%)
  Missing 12 (29.3%) 20 (33.9%)
 Thrombocytopenia
  Yes 6 (14.6%) 4 (6.8%) 0.60
  No 23 (56.1%) 35 (59.3%)
  Missing 12 (29.3%) 20 (33.9%)
 Anemia
  Yes 4 (9.8%) 9 (15.3%) 0.68
  No 25 (61.0%) 30 (50.8%)
  Missing 12 (29.3%) 20 (33.9%)
 Fatigue
  Yes 6 (14.6%) 8 (13.6%) 0.75
  No 23 (56.1%) 29 (49.2%)
  Missing 12 (29.3%) 22 (37.3%)
 Nausea/vomiting
  Yes 1 (2.4%) 7 (11.9%) 0.22
  No 28 (68.3%) 31 (52.5%)
  Missing 12 (29.3%) 21 (35.6%)
 Diarrhea
  Yes 0 (0.0%) 1 (1.7%) 0.62
  No 29 (70.7%) 36 (61.0%)
  Missing 12 (29.3%) 22 (37.3%)
 Neuropathy
  Yes 5 (12.2%) 16 (27.1%) 0.23
  No 24 (58.5%) 25 (42.4%)
  Missing 12 (29.3%) 18 (30.5%)
Allergic reaction
  Yes 1 (2.4%) 0 (0.0%) 0.50
  No 28 (68.3%) 37 (62.7%)
  Missing 12 (29.3%) 22 (37.3%)
 Other
  Yes 4 (9.8%) 10 (16.9%) 0.58
  No 25 (61.0%) 29 (49.2%)
  Missing 12 (29.3%) 20 (33.9%)

Values shown as n (%).

*

All toxicities grade 2 or higher.

Included acute kidney injury, anorexia, constipation, phlebitis, abdominal pain.

N/A, not applicable.