Table 4.
Multivariate analysis of IHC markers and correlation with patient and tumor factors
| PD-1 TILS | PD-L1 IHC | PD-1 positive lymphocytes | PD-L1 CPS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | |
| Age (by 10 years) | 1.29 | 0.91 – 1.83 | 0.154 | 1.26 | 0.91 – 1.75 | 0.168 | 1.21 | 0.857 – 1.70 | 0.2827 | 1.20 | 0.853 – 1.69 | 0.2964 |
| Tumor site | ||||||||||||
| Ovary | Referent | Referent | Referent | Referent | ||||||||
| Uterine | 1.52 | 0.32 – 7.25 | 0.603 | 2.01 | 0.43 – 9.35 | 0.3754 | 2.39 | 0.454 – 12.57 | 0.3041 | 2.48 | 0.484 – 12.70 | 0.2759 |
| Stage | ||||||||||||
| I or II | Referent | Referent | Referent | Referent | ||||||||
| III | 3.37 | 0.94 – 11.99 | 0.061 | 3.77 | 1.01 – 14.02 | 0.048 | 3.82 | 1.084 – 13.48 | 0.0371 | 3.99 | 1.096 – 14.53 | 0.0358 |
| IV | 7.21 | 1.68 – 31.03 | 0.008 | 7.11 | 1.64 – 30.86 | 0.009 | 6.27 | 1.456 – 27.03 | 0.0137 | 6.23 | 1.444 – 26.89 | 0.0142 |
Abbreviations: TILS: tumor infiltrating lymphocytes; CPS: combined positive score; IHC: Immunohistochemistry