Table 2.
Baseline AMD features per classification system
| Drusen | Pigment Changes | Late Changes | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Year | Classification System | Type | Size | Area | Hyper-pigmentation | RPE Degeneration | GA | GA sub* | CNV | Mixed | |
| 2001 | Rotterdam16 | ✓ | ✓ | x | ✓ | ✓ | ✓ | x | ✓ | ✓ | |
| 2001 | AREDS17 | x | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
| 2005 | AREDS 9-step18 | x | x | ✓ | ✓ | ✓ | x | ✓ | x | x | |
| 2005 | AREDS simplified12 | x | ✓ | x | ✓ | ✓ | x | x | x | x | |
| 2013 | Beckman19 | x | ✓ | x | ✓ | ✓ | ✓ | x | ✓ | ✓ | |
| 2014 | 3-Continent harmonization20 | x | ✓ | ✓ | ✓ | ✓ | ✓ | x | ✓ | ✓ | |
*
GA subspecified: classification system subspecified GA into central and noncentral GA.
Abbreviations: CNV, choroidal neovascularization; GA, geographic atrophy; mixed, mixed phenotype of both GA and CNV.