Table 1.

The Concentrations of RBZ and 10×RBZ in the Anterior Chamber, Vitreous, Retina of Rabbit Eyes and Serum at 1 Hour and 1, 4, 8, 14, 30, and 60 Days after Injection

	Anterior chamber Concentration (µg/mL)			Vitreous Concentration (µg/mL)			Retina Concentration (µg/mL)			Serum Concentration (ng/mL)
	RBZ	10×RBZ		RBZ	10×RBZ		RBZ	10×RBZ		RBZ	10×RBZ
Time	0.3 mg/0.03 mL	3.0 mg/0.03 mL	P * value	0.3 mg/0.03 mL	3.0 mg/0.03 mL	P * value	0.3 mg/0.03 mL	3.0 mg/0.03 mL	P * value	0.3 mg/0.03 mL	3.0 mg/0.03 mL	P * value
1 hour	23.08 ± 6.11	181.48 ± 13.72	< 0 .001	140.01 ± 10.85	1637.54 ± 132.74	< 0 .001	76.48 ± 9.32	90.15 ± 6.40	0 .035	3.81 ± 0.52	19.73 ± 1.32	< 0 .001
1 day	14.08 ± 4.47	106.13 ± 9.64	< 0 .001	100.61 ± 8.19	1192.33 ± 105.32	< 0 .001	102.70 ± 11.27	112.90 ± 9.73	0.369	7.35 ± 1.14	22.07 ± 1.93	< 0 .001
4 days	8.69 ± 2.23	77.24 ± 8.48	< 0 .001	51.72 ± 6.47	604.53 ± 48.78	< 0 .001	72.26 ± 5.85	224.68 ± 15.77	< 0 .001	4.56 ± 0.63	11.84 ± 1.46	< 0 .001
8 days	7.80 ± 2.06	64.40 ± 7.31	< 0 .001	17.67 ± 4.26	450.87 ± 29.47	< 0 .001	55.04 ± 4.46	83.80 ± 6.43	0 .001	2.08 ± 0.29	6.93 ± 0.82	< 0 .001
14 days	6.23 ± 1.83	17.08 ± 5.27	< 0 .001	2.13 ± 0.44	171.32 ± 12.79	< 0 .001	0.95 ± 0.17	9.36 ± 2.28	< 0 .001	1.47 ± 0.17	4.58 ± 0.37	< 0 .001
30 days	0.02	0.08 ± 0.02	< 0 .001	0	0.55 ± 0.11	< 0 .001	0.16 ± 0.03	0.57 ± 0.11	0 .001	1.33 ± 0.18	3.37 ± 0.48	< 0 .001
60 days	0	0.01	< 0 .001	0	0	–	0	0.33 ± 0.09	< 0 .001	0	2.26 ± 0.31	< 0 .001

10×RBZ, 10-fold ranibizumab; RBZ, ranibizumab.

P values in boldface indicate statistical significance.

^*Student's t-tests for P values