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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: J Invest Dermatol. 2020 Feb 3;140(9):1743–1752.e4. doi: 10.1016/j.jid.2020.01.015

Scheme 1. Regulation of IGF1R endocytosis and recycling by two potential pathways.

Scheme 1.

Based on our findings we propose two alternate pathways leading to IGF1R internalization and subsequent recycling: (1) Clathrin-associated, flotillin-mediated endocytosis results in fast internalization and recycling of IGF1R; and (2) Clathrin-associated, adaptor-related protein complex 2-mediated endocytosis promotes slower IGF1R internalization and recycling.