TABLE 3.

Cox regression for overall survival

	Univariate regression		Multivariable regression
	HR (95% CI)	P value	HR (95% CI)	P value
Clinical N0
Age at diagnosis	1.02 (1.00-1.04)	.04	1.02 (1.00-1.04)	.08
Male	1.45 (0.90-2.33)	.12
Race
White	Reference
Black	1.03 (0.50-2.12)	.94
Other	1.23 (0.39-3.91)	.73
Charlson-Deyo score
0	Reference
1	0.79 (0.49-1.30)	.36
2+	1.49 (0.80-2.76)	.21
Tumor size	1.11 (1.00-1.24)	.05
Tumor differentiation
Well/moderate	Reference
Poor/undifferentiated	1.35 (0.80-2.26)	.26
Clinical T stage
T1	Reference
T2	1.09 (0.64-1.85)	.75
T3	1.43 (0.83-2.47)	.20
T4	1.13 (0.34-3.73)	.84
Treatment group
Chemoradiation alone	Reference		Reference
Surgery alone	0.57 (0.34-0.93)	.02	0.59 (0.36-0.97)	.04
Preoperative chemoradiation	0.69 (0.42-1.13)	.14	0.83 (0.48-1.40)	.46
Clinical N1-3
Age at diagnosis	1.01 (0.99-1.02	.33	1.00 (0.98-1.01)	.73
Male	1.36 (0.86-2.14)	.19
Race
White	Reference
Black	0.61 (0.25-1.49)	.28
Other	1.23 (0.50-2.99)	.65
Charlson-Deyo score
0	Reference
1	0.86 (0.60-1.24)	.42
2+	1.50 (0.87-2.59)	.14
Tumor size	1.11 (1.04-1.18)	<.01
Tumor differentiation
Well/moderate	Reference
Poor/undifferentiated	1.53 (0.95-2.47)	.08
Clinical T stage
T1	Reference		Reference
T2	1.20 (0.56-2.56)	.64	1.06 (0.49-2.29)	.88
T3	1.54 (0.80-2.99)	.20	1.47 (0.75-2.91)	.27
T4	2.17 (1.01-4.66)	.05	1.81 (0.83-3.93)	.14
Treatment group
Chemoradiation alone	Reference		Reference
Surgery alone	1.15 (0.58-2.29)	.68	1.18 (0.58-2.41)	.66
Preoperative chemoradiation	0.45 (0.32-0.64)	<.01	0.45 (0.31-0.66)	<.01

Note: Bold value indicates statistical significance.

Abbreviations: CI, confidence interval; HR, hazard ratio.