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Hyaluronate-collagen hydrogel crosslinked via strain-promoted azide-alkyne cycloaddition (SPAAC). (a–c) Scheme of the hydrogel formation. (a) Primary amine groups on collagen react with dibenzocyclooctyne-sulfo-N-hydroxysuccinimidyl ester to form collagen-DBCO (Col-DBCO). (b) Amidated hyaluronate react with azido-PEG5-NHS and formed hyaluronate-azide (HA-azide). (c) The SPAAC reaction between DBCO and azide groups formed hyaluronate-collagen networks without producing any byproducts.
