Table-3.
Top predicted transcription factors binding to differentially methylated TSS regions.
| TSS regions | Transcription factor | Weight | p-value | *Significant score |
|---|---|---|---|---|
| chr1:12601-12900 | EGR4 | 8.7 | 1.6E-05 | 4.796 |
| chr1:14401-14700 | ZSCAN4 | 8.3 | 6.3E-06 | 5.201 |
| chr1:18301-18600 | GATA1::TAL1 | 10.1 | 8.1E-06 | 5.092 |
| chr1:23101-23700 | TEAD1 | 9.3 | 2.3E-06 | 5.638 |
| chr1:24301-25200 | ZNF143 | 9.1 | 3.2E-06 | 5.495 |
| chr10:670801-671400 | Foxd3 | 10.3 | 3.5E-06 | 5.456 |
| chr11:110701-111000 | KLF9 | 11.6 | 5.8E-07 | 6.237 |
| chr11:120601-120900 | Dmbx1 | 10.7 | 3.2E-06 | 5.495 |
| chr12:257701-258000 | ZNF384 | 10.2 | 4.8E-07 | 6.319 |
| chr13:365701-366300 | ZNF384 | 10.1 | 1.1E-06 | 5.959 |
| chr14:10801-11100 | NFYA | 9.6 | 1.2E-05 | 4.921 |
| chr14:26401-26700 | SPI1 | 4.7 | 2.9E-05 | 4.538 |
| chr14:301-600 | CTCF | 14.2 | 6.7E-08 | 7.174 |
| chr14:6601-6900 | Foxd3 | 11 | 9.1E-07 | 6.041 |
| chr15:922801-923100 | TBP | 10.7 | 1.5E-06 | 5.824 |
| chr16:324601-324900 | RBPJ | 9.2 | 1E-05 | 5 |
| chr17:193501-194400 | NFIL3 | 10 | 8.4E-06 | 5.076 |
| chr18:366601-366900 | EWSR1-FLI1 | 6.8 | 1.3E-06 | 5.886 |
| chr2:83701-84000 | RELB | 8.9 | 2E-05 | 4.699 |
| chr3:421501-421800 | SNAI2 | 8.7 | 1.7E-06 | 5.77 |
| chr4:55801-56700 | HSF4 | 11.4 | 1.4E-06 | 5.854 |
| chr5:33901-34200 | HIC2 | 8.4 | 1.1E-05 | 4.959 |
| chr6:67201-67500 | Dlx2 | 8.3 | 7.5E-06 | 5.125 |
| chr6:78901-79200 | Arid5a | 10.1 | 3.1E-06 | 5.509 |
| chr7:26101-26400 | SP2 | 12.4 | 4.2E-07 | 6.377 |
| chr7:34801-35400 | Stat5a::Stat5b | 9.9 | 5.7E-06 | 5.244 |
| chr7:43801-44400 | HIF1A | 11.8 | 1.6E-07 | 6.796 |
| chr7:44701-45300 | KLF5 | 11.2 | 8.7E-07 | 6.06 |
| chrX:42301-42600 | Klf1 | 11.1 | 1.7E-06 | 5.77 |
*
Significant score = −log10 (p-value x nb.words). TSS=Transcription start sites