Table 3.
The diagnostic indices of the single method and combined method
| Diagnostic indices | ||||||
|---|---|---|---|---|---|---|
| Examination | Accuracy rate (%) (95% CI) | Sensitivity (%) (95% CI) | Specificity (%) (95% CI) | Youden's index (%) (95% CI) | Positive predictive value (%) (95% CI) | Negative predictive value (%) (95% CI) |
| EBUS‐TBLB | 69.7(58.1–79.8)** | 62.3(49.0–74.4) | 100(78.2–100) | 62.3(27.2–74.4) | 100(90.7–100) | 39.5(24.0–56.6) |
| PPLs ≤20 mm | 52.4(29.8–74.3)*,*** | 37.5(15.2–64.6)**** | 100(47.8–100) | 37.5(−37.0–64.6) | 100(54.1–100) | 33.3(11.8–61.6) |
| PPLs >20 mm | 76.4(63.0–86.8)** | 71.1(55.7–83.6) | 100(69.2–100) | 71.1(24.8–83.6) | 100(89.1–100) | 43.4(23.2–65.5) |
| PET | 77.6(66.6–86.4)* | 78.7(66.3–88.1) | 73.3(44.9–92.2) | 52.0(11.2–80.3) | 92.3(81.5–97.9) | 45.8(25.6–67.2) |
| PPLs ≤20 mm | 61.9(38.4–81.9)*** | 62.5(35.4–84.8) | 60.0(14.7–94.7) | 22.5(−49.9–79.5) | 83.3(51.6–97.9) | 33.3(7.5–70.1) |
| PPLs >20 mm | 83.6(71.2–92.2) | 84.4(70.5–93.5) | 80.0(44.4–97.5) | 64.4(14.9–91.0) | 95.0(83.1–99.4) | 53.3(26.6–78.7) |
| EBUS‐TBLB+PET | 86.8(77.1–93.5) | 90.2(79.8–96.3) | 73.3(44.9–92.2) | 63.5(24.7–88.5) | 93.2(83.5–98.1) | 64.7(38.3–85.8) |
| PPLs ≤20 mm | 71.4(47.8–88.7)*** | 75.0(47.6–92.7) | 60.0(14.7–94.7) | 35.0(−37.7–87.5) | 85.7(57.2–98.2) | 42.9(9.9–81.6) |
| PPLs >20mm | 92.7(82.4–98.0) | 95.6(84.9–99.5) | 80.0(44.4–97.5) | 75.6(29.2–96.9) | 95.6(84.9–99.5) | 80.0(44.4–97.5) |
Note: *P < 0.05 compared to EBUS‐TBLB+PET; **P < 0.01 compared to EBUS‐TBLB+PET; ***P < 0.05 compared to PPLs >20 mm; ****P < 0.01 compared to PPLs >20 mm.
CI, confidence interval.