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. 2020 Jul 7;11(8):2279–2290. doi: 10.1111/1759-7714.13542

Figure 1.

Figure 1

Patient‐derived organoids (PDOs) of NSCLC recapitulate the parental tumor. (a) The PDO phenotype was observed with a bright field microscope, as shown by the black arrows, after one week of culture. Scale bar, 100 μm. (b) Morphological changes of PDOs after the stated number of days in culture. P4 is squamous cell carcinoma; all others are adenocarcinoma. Scale bar, 100 μm. (c) HE‐stained and IHC images of PDOs and their parental tumor tissues. ADC marker TTF‐1 and SCC marker p63 were expressed in tumor tissues and corresponding organoids, respectively. ADC, adenocarcinoma; HE, hematoxylin‐eosin staining; IHC, immunohistochemistry; NSCLC, non‐small cell lung cancer; PDO, patient‐derived organoid; SCC, squamous cell carcinoma; T, tumor; TTF‐1, thyroid transcription factor‐1.