Fig. 1.

Behavioral phenotyping of TS2‐neo mice in the IntelliCage. (A) Schematic illustration of the IntelliCage apparatus. (B) Daily timeline. (C) Schematic illustrations of a behavioral sequencing task composed of acquisition and reversal blocks to assess flexibility. Acquisition and each reversal block include 20 sessions and 9 sessions, respectively. (D) Learning performance and behavioral flexibility were not affected in TS2‐neo mice. The discrimination error rate was based on the total number of visits to the never‐rewarded corner in the first 100 visits in each session. (E) Cumulative error visits in the first 100 visits in the first and last session of acquisition and reversal blocks. n = 8 mice in WT and n = 5 in TS2‐neo mice. Data are mean ± SEM.