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. 2020 Jul 13;10(8):1577–1586. doi: 10.1002/2211-5463.12912

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© 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 4 — GSEA identified potential pathways that are activated or repressed by KLF7 in squamous carcinoma. (A) Volcano plot shows differential expression landscape in KLF7_high samples (n = 251) compared with KLF7_low squamous carcinoma samples (n = 250) from TCGA. Genes with |log₂FC| > 5 and P _adj < 0.05 were specified by their symbols. (B) Heatmap illustrates expression values of genes with |log₂FC| > 5 and P _adj < 0.05 in KLF7_high and KLF7_low squamous carcinoma samples. (C) Details of the top three most significantly enriched KEGG pathways in KLF7_high squamous carcinoma samples. NS, not significant.