TABLE 1.
Prevalence of surface structure and virulence related strain features in invasive S. pyogenes isolates identified through the Active Bacterial Core surveillance system in the United States in 2016 and 2017 (n = 3873).
| Strain featurea | Description | Count (proportion) |
| SPE_G | Streptococcal pyrogenic exotoxin G | 3,500(90.4%) |
| FBAA | Fibronectin-binding protein of group A streptococci type A | 3,204(82.7%) |
| SME_Z | Streptococcal mitogenic exotoxin | 3,123(80.6%) |
| D330G | NADase D330G substitution associated with increased NADase activity | 3,038(78.4%) |
| CAPSULE | hasA hyaluronic acid synthetase operon determinant | 2,650(68.4%) |
| MRP | emm-like mrp virulence gene | 2,609(67.4%) |
| ENN | emm-like enn virulence gene | 2,565(66.2%) |
| SOF | Serum opacity factor | 2,515(64.9%) |
| PRTF2 | S. pyogenes fibronectin-binding protein | 2,477(64%) |
| SFB1 | S. pyogenes fibronectin-binding protein I | 2,424(62.6%) |
| SPE_C | Streptococcal pyrogenic exotoxin C | 2,019(52.1%) |
| PNGA3 | Pnga 3 – Clade 3 up-regulated promoter of the nga operon | 1,865(48.2%) |
| SPE_J | Streptococcal pyrogenic exotoxin J | 1,190(30.7%) |
| SPE_H | Streptococcal pyrogenic exotoxin H | 1,003(25.9%) |
| SPE_I | Streptococcal pyrogenic exotoxin I | 954(24.6%) |
| SDA1 | Virulence associated DNAse | 890(23%) |
| SIC | Streptococcal inhibitor of complement | 826(21.3%) |
| SPE_A | Streptococcal pyrogenic exotoxin A | 788(20.3%) |
| SS_A | Streptococcal Superantigen A | 510(13.2%) |
| SPE_K | Streptococcal pyrogenic exotoxin K | 496(12.8%) |
| R28 | Homolog of a group B streptococcal adhesin | 365(9.4%) |
| SPE_L | Streptococcal pyrogenic exotoxin L | 269(6.9%) |
| SPE_M | Streptococcal pyrogenic exotoxin M | 263(6.8%) |
| ROCA | rocA null mutation conserved within type emm3 strains | 237(6.1%) |
aA strain feature is either positive (presence) or negative (absence) in an isolate.