Table 4.
The Performance of 11C-MET PET metrics and age feature for IDH-mutation prediction.
| PET metric | Cutoff | AUC (95% CI) | ACC | SEN | SPE | PPV | NPV | Youden-index |
|---|---|---|---|---|---|---|---|---|
| SUVSD | ≤ 0.29 | 0.731 (0.638–0.811) | 68.18% | 77.55% | 60.66% | 61.30% | 77.10% | 0.3821 |
| TNRmax | ≤ 2.9886 | 0.678 (0.582–0.764) | 66.36% | 75.51% | 59.02% | 59.70% | 75.00% | 0.3453 |
| TNRmean | ≤ 1.7051 | 0.679 (0.583–0.765) | 65.46% | 69.39% | 62.30% | 59.60% | 71.70% | 0.3168 |
| TNRpeak | ≤ 2.8191 | 0.660 (0.564-0.748) | 65.45% | 79.59% | 54.10% | 58.20% | 76.70% | 0.3369 |
| Age | ≤ 45 | 0.630 (0.533–0.720) | 62.73% | 65.31% | 60.66% | 57.10% | 68.50% | 0.2596 |
| Midline involvement | yes | 0.766 (0.676–0.842) | 74.54% | 95.92% | 57.38% | 64.40% | 94.60% | 0.5330 |
CI, Confidence interval; AUC, Area under the receiver-operating characteristic curve; ACC, Accuracy; SEN, Sensitivity; SPE, Specitivity; PPV, Positive predictive value; NPV, Negative predictive value.