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. 2020 Jul 23;7:439. doi: 10.3389/fvets.2020.00439

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Copyright © 2020 Gray, Turnbull, Meehan, Martínez-Pérez, Kay, Pang and Argyle.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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WNT signaling is increased in MCF-7 RR, ZR-751 RR, and REM-134 RR cell lines. (A) Heatmap showing log2 mean-centered gene expression profiles between parental and RR cell lines in respect of the WNT signaling pathway (left heatmap) and WNT target genes (right heatmap). WNT5a and represented FRIZZLED genes are shown separately for REM-134 and REM-134 RR cell lines (center heatmap). Genes taken from the KEGG pathway database (55); red = higher expression, black = no change, green = lower expression. The gene lists are shown in Supplementary Table 5. Heatmap clustering was carried out using Pearson correlation with average linkage. (B) IHC of pan-Frizzled and WNT5a expression in REM-134 and REM-134 RR MTS with quantitative analysis of the % of positively stained cells (unpaired, two tailed t-test; data expressed as mean ± SEM, n = 3, ****p ≤ 0.0001).