TABLE 2.

Top 10 reactome pathways that enriched for IAV, IBV, or RV infection when compared with mock infection at 12 hpi using g:Profiler analysis.

	IAV			IBV			RV
	Reactome pathway	FDR-adjusted p-value	Enrichment score	Reactome pathway	FDR-adjusted p-value	Enrichment score	Reactome pathway	FDR-adjusted p-value	Enrichment score
1	Interferon signaling	2.1E-27	26.69	Cell cycle	1.4E-20	19.86	Interferon signaling	4.0E-25	24.39
2	Cytokine signaling in immune system	4.1E-27	26.38	Influenza infection	1.7E-20	19.78	Interferon alpha/beta signaling	2.5E-22	21.60
3	Interferon alpha/beta signaling	1.3E-24	23.90	L13a-mediated translational silencing of ceruloplasmin expression	2.6E-20	19.58	Cytokine signaling in immune system	1.2E-17	16.92
4	Immune system	2.3E-21	20.64	Cytokine signaling in immune system	3.4E-20	19.47	Interferon gamma signaling	8.4E-13	12.08
5	Eukaryotic translation elongation	7.4E-20	19.13	Cap-dependent translation initiation	4.4E-20	19.35	Immune system	1.9E-08	7.72
6	Peptide chain elongation	7.4E-20	19.13	Eukaryotic translation initiation	4.4E-20	19.35	Interleukin-4 and Interleukin-13 signaling	6.1E-07	6.21
7	Viral mRNA translation	7.4E-20	19.13	Influenza life cycle	6.5E-20	19.18	Interleukin-10 signaling	8.5E-06	5.07
8	Nonsense mediated decay (NMD) enhanced by EJC	1.4E-19	18.85	Signaling by ROBO receptors	8.8E-20	19.06	Antiviral mechanism by IFN-stimulated genes	2.0E-05	4.70
9	Nonsense-mediated decay (NMD)	1.4E-19	18.85	Cell cycle. Mitotic	1.1E-19	18.95	FOXO-mediated transcription	9.4E-05	4.03
10	Influenza infection	1.6E-19	18.79	GTP hydrolysis and joining of the 60S ribosomal subunit	1.8E-19	18.74	Signaling by interleukins	1.5E-04	3.82