Table 2.
Feature No. | Imaging modality | VOI of feature extraction | Filter type | Feature class | Statistic | Coefficients* |
---|---|---|---|---|---|---|
F1 | Portal venous phase | Tumor | Wavelet_LLL | GLCM | IMC1 | −0.1487 |
F2 | Portal venous phase | Tumor | Wavelet_LLL | GLCM | IMC2 | −0.0177 |
F3 | Portal venous phase | Tumor | Wavelet_HLL | GLRLM | SRLGLE | −0.0282 |
F4 | Arterial phase | Tumor | Wavelet_LHL | GLRLM | SRLGLE | −0.0600 |
F5 | Arterial phase | Peritumoral region | Log.sigma.1.0.mm | GLDM | DNN | −0.1651 |
F6 | Arterial phase | Peritumoral region | Wavelet_LHL | GLSZM | GLNN | −0.0571 |
OS, Overall survival; VOI, Volume of interest; GLCM, Gray Level Co-occurrence Matrix; GLRLM, Gray Level Run Length Matrix; GLCM, Gray Level Co-occurrence Matrix; GLDM, Gray Level Dependence Matrix; GLSZM, Gray Level Size Zone Matrix. IMC, Informational Measure of Correlation; SRLGLE, Short_Run_Low_Gray_Level_Emphasis; DNN, Dependence Non-Uniformity Normalized; GLNN, Gray Level Non-Uniformity Normalized.
Coefficients were derived from the LASSO Cox regression. Formula of the radiomics signature was as follows: radiomics signature = IMC1 × −0.1487 + IMC2 × -0.0177 + SRLGLE × −0.0282 + SRLGLE × −0.0600 +DNN × −0.1651 + GLNN × −0.0571.