TABLE 3.

Multivariate analysis for the six-lncRNA signature of disease-free survival in cohorts.

Variables		Univariate analysis			Multivariate analysis
		HR	95% CI	P-value	HR	95% CI	P-value
Training set GSE21653 (n = 232)
Age		1.006	0.988−1.024	0.533	1.007	0.989-1.026	0.423
ER status
	Positive vs Negative	0.670	0.424−1.059	0.087	0.772	0.468-1.272	0.310
Grade
	Grade II vs Grade I	2.748	1.129−6.691	0.026*	2.881	1.181-7.028	0.020*
	Grade III vs Grade I	3.395	1.437−8.026	0.005*	3.174	1.314-7.666	0.010*
Six-lncRNA signature
	High-risk vs Low-risk	1.674	1.052−2.664	0.030*	1.789	1.122-2.852	0.015*
Validation set GSE42568 (n = 101)
Age		0.995	0.969−1.021	0.700	1.001	0.975-1.027	0.962
ER status
	Positive vs Negative	0.439	0.243−0.793	0.006*	0.472	0.254-0.877	0.017*
Grade
	Grade II vs Grade I	1.497	0.337−6.638	0.596	1.059	0.234-4.788	0.940
	Grade III vs Grade I	3.966	0.943−16.679	0.060	2.880	0.662-12.53	0.158
Six-lncRNA signature
	High-risk vs Low-risk	1.998	1.092−3.655	0.025*	2.327	1.256-4.311	0.007*
Validation set GSE20711 (n = 87)
Age		1.041	1.010−1.073	0.009*	1.043	1.013-1.075	0.005*
ER status
	Positive vs Negative	0.554	0.286−1.070	0.079	0.637	0.308-1.316	0.223
Grade
	Grade II vs Grade I	1.941	0.315−11.947	0.474	2.028	0.275-14.976	0.488
	Grade III vs Grade I	2.564	0.786−8.362	0.118	2.177	0.592-8.013	0.242
Six-lncRNA signature
	High-risk vs Low-risk	1.539	1.021−2.905	0.040*	1.631	1.037-3.105	0.043*