FIGURE 1.

Metabolic network for the heterologous production of sesquiterpenoids. Graphical representation of the various modules involved in recombinant sesquiterpenoid synthesis: mevalonate module (blue), prenyl phosphate module (green), carotenoid module (orange), and recombinant sesquiterpenoid module (pink). Enzyme names are given in Table 1. Enzymes studied in this publication are indicated in red and those that were already studied in U. maydis are underlined (HMG-CoA, 3-hydroxy-3-methylglutaryl-CoA; MVA, mevalonate; MP, mevalonate-5-phosphate; MPP, mevalonate-pyrophosphate; IPP, isoprenyl-pyrophosphate; DMAPP, dimethylallyl-pyrophosphate, GPP, geranyl-pyrophosphate; FPP, farnesyl-pyrophosphate GGPP, geranylgeranyl-pyrophosphate).