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Major randomized clinical trials investigating the effect of low-dose GC therapy in sepsis or septic shock patients.
| Study | Year | # Patients | 28-Day mortality in control group | Treatment start | Mortality benefit | Shock reversal | References |
|---|---|---|---|---|---|---|---|
| Annane et al. | 2002 | 299 | 61% | ≤ 8 h | 6% | 2 days | (112) |
| CORTICUS | 2008 | 499 | 36.1% | ≤ 72 h | No | 3.3 days | (113) |
| HYPRESS | 2016 | 380 | 8.2% | ≤ 48 h | No | No | (114) |
| ADRENAL | 2018 | 3,800 | 24.3% | 20 ± 90 h | No | 1 day | (115) |
| APROCCHSS | 2018 | 1,241 | 38.9% | ≤ 24 h | 6.1% | 2 days | (116) |
